Insulin Shenanigans: Resistance, Metabolic Mischief, and Disease Dominoes

Insulin plays an important role in regulating glucose absorption and maintaining metabolic balance in our body. However, when cells become insulin resistant, it can lead to a series of metabolic and growth imbalances that can increase the risk of chronic diseases.

Metabolic function: Insulin is a hormone that is produced by the pancreas. It plays an important role in regulating glucose levels in the body by helping cells absorb glucose for energy. Insulin also inhibits glucose production in the liver and promotes the storage of glycogen. When the pancreas cannot produce enough insulin to overcome resistance, cells are unable to absorb glucose properly, leading to high blood sugar levels. This triggers a vicious cycle of insulin resistance and hyperinsulinemia, which promotes further imbalances such as an overstimulation of the mitogenic effects.

Mitogenic function: Apart from its metabolic functions, insulin also promotes cell growth and division. When cells become resistant to insulin, it mostly affects the metabolic function leading to potential overstimulation of cell growth and proliferation. This can result in various health problems such as abnormal growth of fat cells, atherosclerosis, polycystic ovaries, and so on. A high insulin level, combined with an impaired ability to control cell growth, can also create an environment that is conducive to cancer growth.

It is important to understand the complex connections between insulin resistance and its downstream effects. Making lifestyle modifications, such as maintaining a balanced diet and regular exercise, can help break the chain of insulin resistance and safeguard metabolic and overall health. Early intervention and preventative measures are crucial in managing insulin resistance and preventing chronic diseases.